5-METHYL-2-NITROPHENYLBORONIC ACID - Names and Identifiers
5-METHYL-2-NITROPHENYLBORONIC ACID - Physico-chemical Properties
| Molecular Formula | C7H8BNO4
|
| Molar Mass | 180.95372 |
5-METHYL-2-NITROPHENYLBORONIC ACID - Introduction
5-Methyl-2-nitrobenzeneboronic acid is an organic compound with the chemical formula C7H8BNO4. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: A white to light yellow crystal or crystalline powder
-Melting point: about 125-129 ° C
-Solubility: Soluble in some organic solvents, such as dimethyl sulfoxide, acetonitrile and dichloromethane
Use:
- 5-methyl -2-nitrobenzene boronic acid is an important organic synthesis intermediate, which is commonly used in boron enol acid coupling reaction and Suzuki coupling reaction in organic synthesis reaction.
-It can be used to synthesize a variety of organic compounds, such as heterocyclic compounds, natural products and drugs.
Method:
- 5-methyl -2-nitrobenzene boronic acid can be prepared by a variety of synthetic routes. One of the common preparation methods is described below:
1. First, 2-nitropentafluorobenzene is reacted with methyl lithium under mild conditions to generate 2-nitrophenyl lithium.
2. Then, the generated 2-nitrophenyl lithium and trimethoxyborane (trimethylboroxine) are reacted to generate 5-methyl -2-nitrobenzene boronic acid.
Safety Information:
- 5-methyl -2-nitrobenzene boric acid is a combustible, avoid contact with high temperature and open flame.
-Wear appropriate protective gloves and eye protection when handling the compound.
-Avoid inhaling its dust or solution, pay attention to protective measures, and ensure that the operation is carried out in a well-ventilated place.
-If the compound is touched externally, rinse it thoroughly with water and seek medical attention promptly.
Last Update：2024-04-09 21:01:54